Title: White matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study
year: 2010
Journal: Schizophr Res
Volume: 119
Issue: 01/03/2016
Pages: 52-60
Epubdate: 09/01/2010
date: Jun
Alternate Journal: Schizophrenia research
DOI: 10.1016/j.schres.2009.12.012
Accession Number: 20056394
Abstract: This study examined white matter volume change and integrity jointly in patients with first-episode schizophrenia using an empirically derived region of interest approach and novel Diffusion Tensor Imaging (DTI) geometric indices. Structural images from 103 individuals comprising of 39 patients with first-episode schizophrenia and 64 healthy controls were examined for regions of white matter volume change using voxel-based morphometry (VBM). These regions were then further interrogated for group differences employing geometric indices in addition to fractional anisotropy (FA).VBM analyses revealed that patients with first-episode schizophrenia had lower white matter volume in the right temporal-occipital region (p<0.005) corresponding to the inferior longitudinal fasciculus. Further analyses of diffusion anisotropy in the right temporal-occipital region revealed lower planar anisotropy, and higher linear anisotropy (p=0.012) in patients. FA in the implicated region was also found to be correlated with severity of delusions (r=0.47, p=0.004).We confirmed previous findings of lower white matter volume in the region of inferior longitudinal fasciculus. The presence of changes in geometric diffusion indices in the implicated white matter region suggested that pathophysiological processes which underlie cerebral white matter volume reduction may not be reflected by changes in FA. Further research is needed to better understand the nature of these white matter changes and its progression in schizophrenia over time.
URI: https://open-access.imh.com.sg/handle/123456789/4463
Authors Address: Research Division
Institute of Mental Health
Database Provider: NLM
language: eng
Appears in Collections:2010

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