Title: Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia
year: 2010
Journal: Psychiatry Res
Volume: 176
Issue: 1
Pages: 08/12/2016
Epubdate: 20/01/2010
date: 01/03/1930
Alternate Journal: Psychiatry research
ISSN: 0165-1781 (Print)
DOI: 10.1016/j.psychres.2009.08.023
Accession Number: 20083312
Abstract: Sex differences in the onset, epidemiology, clinical presentation and neuropathology of schizophrenia suggest that sexual dimorphism in brain development may be relevant to pathogenesis. Sex hormones, in particular testosterone, are considered to be crucial in brain development, but few investigations have examined the potential role of prenatal testosterone in schizophrenia. In this study, we examined a retrospective marker of prenatal testosterone release - 2D:4D finger length ratio (2D:4D), the relative length of 2nd to 4th digit, in 64 Asian patients with schizophrenia and 64 sex-matched controls. No significant difference in mean finger lengths was present, however 2D:4D ratio was significantly different between patients and controls. The effect was primarily seen in males consistent with a 'less masculinised' pattern and hypotheses suggesting that schizophrenia may be associated with an abnormality in prenatal circulating testosterone.
URI: https://open-access.imh.com.sg/handle/123456789/4465
Authors Address: Department of Psychology
National University of Singapore
Singapore. psycsl@nus.edu.sg
Database Provider: NLM
language: eng
Appears in Collections:2010

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