Title: Weight gain in Asian patients on second-generation antipsychotics
year: 2010
Journal: Ann Acad Med Singapore
Volume: 39
Issue: 2
Pages: 118-21
Epubdate: 20/03/2010
date: Feb
Alternate Journal: Annals of the Academy of Medicine, Singapore
ISSN: 0304-4602 (Print)
Accession Number: 20237733
Abstract: INTRODUCTION: There is increasing evidence that second-generation antipsychotics are associated with weight gain. However almost all available literature has been for Caucasian populations. MATERIALS AND METHODS: A health quality improvement project was undertaken at the Institute of Mental Health/Woodbridge Hospital to monitor patients who were started on second-generation antipsychotics. This 2-year survey of 266 patients on second-generation antipsychotics closely tracked weight gain and other physical and biochemical parameters. RESULTS: Of the 222 patients regularly monitored, 78.4% had weight gain (mean weight gain 1.9 kg, maximum weight gain 20.1 kg). Weight gain group liability was highest for clozapine (72.4%), followed by olanzapine (66.7%) and risperidone (65%). Most of the weight gain occurred in the fi rst 4 weeks of treatment and 95.9% of those who gained weight had done so in the fi rst 6 months. The maximum weight gain was seen at 12 weeks for risperidone and 8 weeks for clozapine, quetiapine and olanzapine; the latter having another peak at 6 months. CONCLUSION: The survey confirms that weight gain is also a problem for Asian patients treated with second-generation antipsychotics. It reinforces the need for the regular monitoring of patients and the need for psychoeducation and advice on diet and a healthy lifestyle.
URI: https://open-access.imh.com.sg/handle/123456789/4480
Authors Address: Institute of Mental Health/Woodbridge Hospital
Singapore. rathi_mahendran@imh.com.sg
Database Provider: NLM
language: eng
Appears in Collections:2010

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