Title: Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations
year: 2010
Journal: Subst Use Misuse
Volume: 45
Issue: 01/02/2016
Pages: 01/01/2014
Epubdate: 23/12/2009
Alternate Journal: Substance use & misuse
ISSN: 1082-6084
DOI: 10.3109/10826080802490584
Accession Number: 20025435
Abstract: The association between two functional polymorphisms in alcohol dehydrogenase (ADH2/ADH1B) and aldehyde dehydrogenase (ALDH2) genes and alcohol dependence was examined in 182 Chinese and Indian patients undergoing treatment for alcohol dependence and 184 screened control subjects from Singapore. All subjects were screened by the Alcohol Use Disorders Identification Test (AUDIT). Patients were also administered the Severity of Alcohol Dependence Questionnaire (SADQ). Polymorphisms were genotyped by allele-specific polymerase chain reaction and selected genotypes confirmed by DNA sequencing or restriction fragment length polymorphism. Our results showed that frequencies of ADH1B*2 and ALDH2*2 were higher in controls compared to alcohol-dependent subjects for both Chinese and Indians. Frequencies of these two alleles were also higher in the 104 Chinese controls compared to the 80 Indian controls. None of the eight Chinese who were homozygous for both protective alleles was alcohol dependent. The higher frequencies of the protective alleles could explain the lower rate of alcohol dependence in Chinese.
URI: https://open-access.imh.com.sg/handle/123456789/4495
Authors Address: KK Research Centre
KK Women's and Children's Hospital
Singapore. tanec@bigfoot.com
Database Provider: NLM
language: eng
Appears in Collections:2010

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