Title: Asymmetry loss is local rather than global in adolescent onset schizophrenia
year: 2010
Journal: Schizophr Res
Volume: 120
Issue: 01/03/2016
Pages: 84-6
Epubdate: 11/05/2010
date: Jul
Alternate Journal: Schizophrenia research
DOI: 10.1016/j.schres.2009.12.032
Accession Number: 20452748
Abstract: Meta-analyses in adult-onset schizophrenia report loss of normal planum temporale (PT) asymmetry, posited to relate to language and symptoms, but are inconclusive regarding global "cerebral torque". PT asymmetry has been reported unchanged in childhood onset schizophrenia. Here the discrepancy is examined in adolescence. Unbiased PT asymmetry and torque measures were obtained on 35 adolescents with schizophrenia or schizoaffective disorder and 31 adolescent controls. Patients had less PT asymmetry than controls, but torque was unchanged. Taken with previous reports, these results in adolescent onset psychosis suggest that local disturbance of cerebral asymmetry increases with patient age; it could indicate that differential rate of change at the cortical surface in the two hemispheres is the mechanism of symptom generation.
URI: https://open-access.imh.com.sg/handle/123456789/4507
Authors Address: College of Medicine
University of Iowa
Iowa City
IA 52242
USA.
Database Provider: NLM
language: eng
Appears in Collections:2010

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