Title: Arcuate fasciculus abnormalities and their relationship with psychotic symptoms in schizophrenia
year: 2012
Journal: PLoS One
Volume: 7
Issue: 1
Pages: e29315
Epubdate: 14/01/2012
Alternate Journal: PloS one
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0029315
PMCID: PMC3252319
Accession Number: 22242165
Abstract: Disruption of fronto-temporal connections involving the arcuate fasciculus (AF) may underlie language processing anomalies and psychotic features such as auditory hallucinations in schizophrenia. No study to date has specifically investigated abnormalities of white matter integrity at particular loci along the AF as well as its regional lateralization in schizophrenia. We examined white matter changes (fractional anisotropy (FA), axial diffusivity (AD), asymmetry indices) along the whole extent of the AF and their relationship with psychotic symptoms in 32 males with schizophrenia and 44 healthy males. Large deformation diffeomorphic metric mapping and Fiber Assignment Continuous Tracking were employed to characterize FA and AD along the geometric curve of the AF. Our results showed that patients with schizophrenia had lower FA in the frontal aspects of the left AF compared with healthy controls. Greater left FA and AD lateralization in the temporal segment of AF were associated with more severe positive psychotic symptoms such as delusions and hallucinations in patients with schizophrenia. Disruption of white matter integrity of the left frontal AF and accentuation of normal left greater than right asymmetry of FA/AD in the temporal AF further support the notion of aberrant fronto-temporal connectivity in schizophrenia. AF pathology can affect corollary discharge of neural signals from frontal speech/motor initiation areas to suppress activity of auditory cortex that may influence psychotic phenomena such as auditory hallucinations and facilitate elaboration of delusional content.
URI: https://open-access.imh.com.sg/handle/123456789/4557
Authors Address: Division of Bioengineering
National University of Singapore
Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2012




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