Title: Symptomatic and functional remission in patients with first-episode psychosis
year: 2012
Journal: Acta Psychiatr Scand
Volume: 126
Issue: 4
Pages: 282-9
Epubdate: 24/05/2012
date: Oct
Alternate Journal: Acta psychiatrica Scandinavica
ISSN: 0001-690x
DOI: 10.1111/j.1600-0447.2012.01883.x
Accession Number: 22616617
Abstract: OBJECTIVE: For patients suffering from psychotic disorders and their caregivers, 'recovery' remains important. Our study aims to examine the rates of both symptomatic and functional remission in first-episode psychosis (FEP) patients at 2 years and identify sociodemographic and clinical factors associated with recovery. METHOD: In this naturalistic study, all consecutive FEP patients presenting to an early psychosis intervention programme were recruited. Symptomatic remission was defined by the Schizophrenia Working Group's criteria; functional remission was defined as a Global Assessment of Functioning (GAF) disability score of >/=61 with engagement in age-appropriate vocation. Simple and multiple logistic regressions using stepwise method were used. RESULTS: Out of 1175 patients, 636 (54.1%) met criteria for symptomatic remission, 686 (58.4%) for functional remission, while 345 (29.4%) met for both. Multiple logistic regression revealed female gender (OR 1.47; 95%CI, 1.12-1.93), those married (OR 1.49; 95%CI, 1.02-2.18), younger age (OR 0.98; 95%CI, 0.95-0.99), tertiary education (OR 1.56; 95%CI, 1.02-2.38), shorter DUP (OR 0.99; 95%CI, 0.98-0.99), lower baseline PANSS negative scores (OR 0.97; 95%CI, 0.95-0.99), and early response at month 3 (OR 1.78; 95%CI, 1.31-2.42), as significant predictors of recovery at year 2. CONCLUSION: Our results indicate that strategies to reduce DUP and achieve early response could improve remission rates in FEP patients.
URI: https://open-access.imh.com.sg/handle/123456789/4591
Authors Address: Department of Early Psychosis Intervention
Institute of Mental Health
Singapore. swapna_verma@imh.com.sg
Database Provider: NLM
language: eng
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