Title: The Longitudinal Youth at Risk Study (LYRIKS)--an Asian UHR perspective
year: 2013
Journal: Schizophr Res
Volume: 151
Issue: 01/03/2016
Pages: 279-83
Epubdate: 22/10/2013
date: Dec
Alternate Journal: Schizophrenia research
ISSN: 0920-9964
DOI: 10.1016/j.schres.2013.09.025
Accession Number: 24139196
Abstract: Numerous studies have been published on the psychosis prodrome and have explored a wide array of its many aspects. However, the set of risk factors identified by these various efforts is not homogenous across studies. This could be due to unique population factors or relatively small sample sizes. Only few studies were conducted on Asian populations, whose socio-cultural characteristics differ - in some cases remarkably - from those in western populations. Singapore is a highly dense city-state in South-east Asia, with low rates of substance abuse. The Longitudinal Youth at Risk Study (LYRIKS) commenced in Singapore in 2008, designed to comprehensively assess a group of ultra high risk (UHR) individuals and identify clinical, social, neuropsychological and biological risk factors unique to the local population. 173 UHR individuals were recruited from this single-site study over 4 years. Here, we detail aspects of the study methodology and report on the baseline social and clinical characteristics of the sample population. 78% of the UHR sample suffered from a psychiatric disorder, with Major Depressive Disorder present in more than half of the sample. The mean Global Assessment of Functioning (GAF) score was 57.4, which indicated a moderate level of impairment. Although the recruited sample did not differ significantly by social and clinical characteristics when compared to previously published reports, the conversion rate to psychosis was 3.5% (n=6) at 6 months. Follow-up measures are currently underway to assess longitudinal incidence of psychosis and impact of risk factors on cognition, functioning and remission.
Notes: 1573-2509
Lee, Jimmy
Rekhi, Gurpreet
Mitter, Natasha
Bong, Yioe Ling
Kraus, Michael S
Lam, Max
Rapisarda, Attilio
Lee, Tih-Shih
Subramaniam, Mythily
Chong, Siow Ann
Keefe, Richard S E
Journal Article
Research Support, Non-U.S. Gov't
Schizophr Res. 2013 Dec
151(1-3):279-83. doi: 10.1016/j.schres.2013.09.025. Epub 2013 Oct 15.
URI: https://open-access.imh.com.sg/handle/123456789/4631
Authors Address: Research Division, Institute of Mental Health, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore. Electronic address: Jimmy_lee@imh.com.sg.
Database Provider: NLM
language: eng
Appears in Collections:2013

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