Title: Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: review of the evidence
year: 2013
Journal: Neurosci Biobehav Rev
Volume: 37
Issue: 3
Pages: 418-35
Epubdate: 16/01/2013
date: Mar
Alternate Journal: Neuroscience and biobehavioral reviews
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2013.01.003
Accession Number: 23318228
Abstract: Longitudinal studies of biological domains in bipolar disorder (BD) are crucial in determining if such baseline changes are progressive. We reviewed reported studies of longitudinal brain structural/functional magnetic resonance imaging (MRI) and neuropsychological changes in BD through November 2012. Longitudinal brain structural MRI studies suggest cortical and subcortical abnormalities within networks subserving emotional regulation. There is evidence of neuroprogressive loss of gray matter volume in prefrontal and anterior cingulate cortex and the subgenual region, with less consistent findings in temporal and subcortical regions. Abnormal amygdala neurodevelopment is noted in adolescent onset BD and possible changes in hippocampus require further evaluation. The fewer reported longitudinal functional MRI studies suggest neurobiological changes in activation patterns involving fronto-limbic circuitry which relate to different illness phase and mood states. Early onset pediatric/adolescent BD may signify a more malignant course of illness in which extensive and executive neurocognitive deficits are found early and may persist, with some potential for improvement during remission and perhaps with treatment. Future studies should include larger samples, combine investigational modalities, incorporate genetic profiles, consider standardization of assessments and collaborative ventures across institutions, selection of more homogeneous subgroups and track neurobiological changes longer to clarify trajectories of changes.
Notes: 1873-7528
Lim, Chin Siang
Baldessarini, Ross J
Vieta, Eduard
Yucel, Murat
Bora, Emre
Sim, Kang
Journal Article
Research Support, Non-U.S. Gov't
Review
United States
Neurosci Biobehav Rev. 2013 Mar
37(3):418-35. doi: 10.1016/j.neubiorev.2013.01.003. Epub 2013 Jan 12.
URI: https://open-access.imh.com.sg/handle/123456789/4633
Authors Address: School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2013

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