Title: An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia
year: 2013
Journal: PLoS One
Volume: 8
Issue: 11
Pages: e80696
Epubdate: 28/11/2013
Alternate Journal: PloS one
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0080696
PMCID: PMC3838413
Accession Number: 24278305
Abstract: Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.
Notes: 1932-6203
Liu, Jiewei
Numata, Shusuke
Ikeda, Masashi
Watanabe, Yuichiro
Zheng, Xue-Bin
Luo, Xiongjian
Kinoshita, Makoto
Nunokawa, Ayako
Someya, Toshiyuki
Ohmori, Tetsuro
Bei, Jin-Xin
Chong, Siow-Ann
Lee, Jimmy
Li, Zhiqiang
Liu, Jianjun
Iwata, Nakao
Shi, Yongyong
Li, Ming
Su, Bing
Journal Article
Research Support, Non-U.S. Gov't
United States
PLoS One. 2013 Nov 22
8(11):e80696. doi: 10.1371/journal.pone.0080696. eCollection 2013.
URI: https://open-access.imh.com.sg/handle/123456789/4634
Authors Address: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China ; University of Chinese Academy of Sciences, Beijing, China.
Database Provider: NLM
language: eng
Appears in Collections:2013

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