Title: Use of clozapine in older Asian patients with schizophrenia between 2001 and 2009
year: 2013
Journal: PLoS One
Volume: 8
Issue: 6
Pages: e66154
Epubdate: 14/06/2013
Alternate Journal: PloS one
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0066154
PMCID: PMC3677908
Accession Number: 23762478
Abstract: BACKGROUND: To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009. METHOD: Information on 1,157 hospitalized patients with schizophrenia aged 50 or older in five East Asian countries and territories (China, Hong Kong, Korea, Singapore and Taiwan) was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) project. Socio-demographic and clinical characteristics and prescription of psychotropic medications were recorded. RESULTS: Clozapine was prescribed for 20.6% of the pooled sample; 19.0% in 2001, 19.4% in 2004 and 22.9% in 2009. Multiple logistic regression analysis of the whole sample revealed that patients taking clozapine had a longer duration of illness, more negative symptoms and were less likely to receive first generation antipsychotic and anticholinergic drugs, but more likely to report weight gain compared to those not receiving clozapine. Compared to those in other sites, older patients in China were more likely to receive clozapine. CONCLUSIONS: The prescription of clozapine for older Asian schizophrenia inpatients has remained at a stable level during the past decade. The appropriateness of use of clozapine in China needs to be further explored.
Notes: 1932-6203
Xiang, Yu-Tao
Buchanan, Robert W
Ungvari, Gabor S
Chiu, Helen F K
Lai, Kelly Y C
Li, You-Hong
Si, Tian-Mei
Wang, Chuan-Yue
Lee, Edwin H M
He, Yan-Ling
Yang, Shu-Yu
Chong, Mian-Yoon
Kua, Ee-Heok
Fujii, Senta
Sim, Kang
Yong, Michael K H
Trivedi, Jitendra K
Chung, Eun-Kee
Udomratn, Pichet
Chee, Kok-Yoon
Sartorius, Norman
Tan, Chay-Hoon
Shinfuku, Naotaka
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
United States
PLoS One. 2013 Jun 10
8(6):e66154. doi: 10.1371/journal.pone.0066154. Print 2013.
URI: https://open-access.imh.com.sg/handle/123456789/4683
Authors Address: Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China ; Beijing Anding Hospital, Capital Medical University, Beijing, China. xyutly@gmail.com
Database Provider: NLM
language: eng
Appears in Collections:2013

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