Title: Adjunctive antidepressant prescriptions for hospitalized patients with schizophrenia in Asia (2001-2009)
year: 2013
Journal: Asia Pac Psychiatry
Volume: 5
Issue: 2
Pages: E81-7
Epubdate: 17/07/2013
date: Jun
Alternate Journal: Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
ISSN: 1758-5864
DOI: 10.1111/j.1758-5872.2012.00231.x
Accession Number: 23857816
Abstract: INTRODUCTION: Little is known about the prescription patterns of adjunctive antidepressants in Asian schizophrenia patients. This study aimed to examine trends in the use of antidepressants and their demographic and clinical correlates in the treatment of schizophrenia in Asia between 2001 and 2009. METHODS: A total of 6,761 hospitalized schizophrenia patients in nine Asian countries and territories were examined: 2,399 in 2001, 2,136 in 2004 and 2,226 in 2009. Patients' socio-demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. RESULTS: The proportion of antidepressant prescription was 6.8% in the whole sample; 5.3% in 2001, 6.5% in 2004 and 8.7% in 2009. There were wide inter-country variations at each survey ranging from 0.9% in Hong Kong to 15.3% in Singapore in 2001; from 1.9% in Korea to 15.4% in Singapore in 2004; and from 2.7% in Japan to 22.0% in Singapore in 2009. Multiple logistic regression analysis of the whole sample revealed that patients on antidepressants were younger, more likely to receive benzodiazepines and have significant extrapyramidal side-effects and less likely to have significant positive symptoms. DISCUSSION: Unlike findings in Western countries, adjunctive antidepressant prescription for schizophrenia was not common in Asia. The frequency of antidepressant prescription varied among countries and territories, suggesting that a host of clinical and socio-cultural factors played a role in determining antidepressant use in Asia.
Notes: 1758-5872
Xiang, Yu-Tao
Ungvari, Gabor S
Wang, Chuan-Yue
Si, Tian-Mei
Lee, Edwin H M
Chiu, Helen F K
Lai, Kelly Y C
He, Yan-Ling
Yang, Shu-Yu
Chong, Mian-Yoon
Tan, Chay-Hoon
Kua, Ee-Heok
Fujii, Senta
Sim, Kang
Yong, Michael K H
Trivedi, Jitendra K
Chung, Eun-Kee
Udomratn, Pichet
Chee, Kok-Yoon
Sartorius, Norman
Shinfuku, Naotaka
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Australia
Asia Pac Psychiatry. 2013 Jun
5(2):E81-7. doi: 10.1111/j.1758-5872.2012.00231.x. Epub 2012 Aug 29.
URI: https://open-access.imh.com.sg/handle/123456789/4684
Authors Address: Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China. xyutly@gmail.com
Database Provider: NLM
language: eng
Appears in Collections:2013

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