Title: Tracking cerebral white matter changes across the lifespan: insights from diffusion tensor imaging studies
year: 2013
Journal: J Neural Transm (Vienna)
Volume: 120
Issue: 9
Pages: 1369-95
Epubdate: 19/01/2013
date: Sep
Alternate Journal: Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 0300-9564
DOI: 10.1007/s00702-013-0971-7
Accession Number: 23328950
Abstract: Delineating the normal development of brain white matter (WM) over the human lifespan is crucial to improved understanding of underlying WM pathology in neuropsychiatric and neurological conditions. We review the extant literature concerning diffusion tensor imaging studies of brain WM development in healthy individuals available until October 2012, summarise trends of normal development of human brain WM and suggest possible future research directions. Temporally, brain WM maturation follows a curvilinear pattern with an increase in fractional anisotropy (FA) from newborn to adolescence, decelerating in adulthood till a plateau around mid-adulthood, and a more rapid decrease of FA from old age onwards. Spatially, brain WM tracts develop from central to peripheral regions, with evidence of anterior-to-posterior maturation in commissural and projection fibres. The corpus callosum and fornix develop first and decline earlier, whilst fronto-temporal WM tracts like cingulum and uncinate fasciculus have protracted maturation and decline later. Prefrontal WM is most vulnerable with greater age-related FA reduction compared with posterior WM. Future large scale studies adopting longitudinal design will better clarify human brain WM changes over time.
Notes: 1435-1463
Yap, Qian Jun
Teh, Irvin
Fusar-Poli, Paolo
Sum, Min Yi
Kuswanto, Carissa
Sim, Kang
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Austria
J Neural Transm (Vienna). 2013 Sep
120(9):1369-95. doi: 10.1007/s00702-013-0971-7. Epub 2013 Jan 18.
URI: https://open-access.imh.com.sg/handle/123456789/4688
Authors Address: School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2013

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