Title: Metabolic complications of schizophrenia and antipsychotic medications--an updated review
year: 2013
Journal: East Asian Arch Psychiatry
Volume: 23
Issue: 1
Pages: 21/08/2016
Epubdate: 29/03/2013
date: Mar
Alternate Journal: East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan
ISSN: 2078-9947
Accession Number: 23535629
Abstract: Metabolic syndrome is a cluster of risk factors comprising obesity, dyslipidaemias, glucose intolerance, insulin resistance (or hyperinsulinaemia), and hypertension, and is highly predictive of type 2 diabetes mellitus and cardiovascular disease. The life expectancy of people with schizophrenia is reduced by 20%, with 60% of the excess mortality due to physical illness. Schizophrenia itself may be a risk factor for metabolic syndrome and there is also increasing concern that antipsychotic drugs, particularly second-generation antipsychotics, have metabolic consequences that contribute to the risk. Various diagnostic guidelines, updated facts with regard to epidemiology, pathophysiology, risk factors, and complications of metabolic syndrome are discussed in this review. Moreover, the impact of various antipsychotics on metabolic syndrome and their possible mechanisms are comprehensively reviewed. The authors emphasise that, while many adults with schizophrenia receive little or no medical care, such care is important given the risk of metabolic abnormalities associated not only with antipsychotic medications, but also with schizophrenia in general.
Notes: 2224-7041
Yogaratnam, J
Biswas, N
Vadivel, R
Jacob, R
Journal Article
East Asian Arch Psychiatry. 2013 Mar
URI: https://open-access.imh.com.sg/handle/123456789/4690
Authors Address: Institute of Mental Health / Woodbridge Hospital, Singapore. jegany@gmail.com
Database Provider: NLM
language: eng
Appears in Collections:2013

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