Title: Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients
year: 2014
Journal: Br J Psychiatry
Volume: 204
Issue: 1
Pages: 55-60
Epubdate: 10/11/2013
date: Jan
Alternate Journal: The British journal of psychiatry : the journal of mental science
ISSN: 0007-1250
DOI: 10.1192/bjp.bp.113.127886
Accession Number: 24202961
Abstract: BACKGROUND: Abnormalities in the corpus callosum have been reported in patients with schizophrenia for over 30 years but the influence of inter-individual differences and illness characteristics remains to be fully elucidated. AIMS: To examine the influence of individual and illness characteristics on the corpus callosum in Chinese Singaporean patients with schizophrenia. METHOD: Using magnetic resonance and diffusion tensor imaging, mean corpus callosum area, volume and fractional anisotropy were investigated in 120 Chinese Singaporean patients (52 with chronic and 68 with first-episode schizophrenia) and compared with data from 75 matched healthy controls. RESULTS: Both area and volume were significantly reduced in patients relative to controls but no significant differences in corpus callosum existed between genders in either patients or controls. Differences in area and volume of the corpus callosum were greatest in patients whose condition was chronic relative to patients with a first episode and controls. Anterior callosum in patients, regardless of chronicity, was no different to that of controls. CONCLUSIONS: Morphological abnormalities in the corpus callosum may increase with illness progression.
Notes: 1472-1465
Collinson, Simon L
Gan, Swu Chyi
Gan, Swu Chyi
Woon, Puay San
Kuswanto, Carissa
Sum, Min Yi
Yang, Guo Liang
Lui, Ji Min
Sitoh, Yih Yian
Nowinski, Wieslaw L
Sim, Kang
Journal Article
Research Support, Non-U.S. Gov't
England
Br J Psychiatry. 2014 Jan
204(1):55-60. doi: 10.1192/bjp.bp.113.127886. Epub 2013 Nov 7.
URI: https://open-access.imh.com.sg/handle/123456789/4753
Authors Address: Simon L. Collinson, DPhil, Department of Psychology, National University of Singapore and Research Division, Woodbridge Hospital/Institute of Mental Health, Singapore
Swu Chyi Gan, MSocSci, Department of Psychology, National University of Singapore, Singapore
Puay San Woon, BSc, Carissa Kuswanto, MSc, Min Yi Sum, BA, Research Division, Woodbridge Hospital/Institute of Mental Health, Singapore
Guo Liang Yang, PhD, Ji Min Lui, PhD, Biomedical Imaging Laboratory, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore
Yih Yian Sitoh, Department of Neuroradiology, National Neuroscience Institute, Singapore
Wieslaw L. Nowinski, DSc, PhD, Biomedical Imaging Laboratory, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore
Kang Sim, MBBS, MMed, FAMS, Research Division and Department of General Psychiatry, Woodbridge Hospital/Institute of Mental Health, Singapore.
Appears in Collections:2014




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