Title: Common use of high doses of antipsychotic medications in older Asian patients with schizophrenia (2001-2009)
year: 2014
Journal: Int J Geriatr Psychiatry
Volume: 29
Issue: 4
Pages: 359-66
Epubdate: 14/08/2013
date: Apr
Alternate Journal: International journal of geriatric psychiatry
ISSN: 0885-6230
DOI: 10.1002/gps.4011
Accession Number: 23939789
Abstract: OBJECTIVE: This study aimed to examine the use of high doses of antipsychotic medications (>/=600 mg/day chlorpromazine equivalent) in older Asian patients with schizophrenia and its demographic and clinical correlates. METHOD: Information on hospitalized patients with schizophrenia aged >/=50 years was extracted from the database of the Research on Asian Psychotropic Prescription Patterns study (2001-2009). Data on 2203 patients in six Asian countries and territories, including China, Hong Kong, Japan, Korea, Singapore and Taiwan, were analyzed. Socio-demographic and clinical characteristics and antipsychotic prescriptions were recorded. RESULTS: The frequency for high-dose antipsychotic medications was 36.0% overall, with 38.4% in 2001, 33.3% in 2004 and 36.0% in 2009. Multiple logistic regression analysis of the whole sample showed that compared to patients receiving low-medium antipsychotic doses, those on high doses had a longer illness duration (odds ratio (OR): 2.0, 95% confidence interval (CI):1.2-3.3, p = 0.008), were more likely in the 50-59-year group (OR: 0.95, 95% CI: 0.94-0.97, p < 0.001), more often had current positive (OR: 1.5, 95% CI: 1.2-1.8, p < 0.001) or negative symptoms (OR: 1.3, 95% CI: 1.03-1.6, p = 0.03), and more commonly received antipsychotic polypharmacy (OR: 5.3, 95% CI: 4.1-6.7, p < 0.001). Extrapyramidal symptoms (p = 0.25) and tardive dyskinesia (p = 0.92) were not more frequent in the high-dose group. CONCLUSIONS: High doses of antipsychotic medications were used in more than one third of older Asian patients with schizophrenia. The reasons for the frequent use of high antipsychotic doses in older Asian patients warrant further investigation.
Notes: 1099-1166
Xiang, Yu-Tao
Li, Yan
Correll, Christoph U
Ungvari, Gabor S
Chiu, Helen F K
Lai, Kelly Y C
Tang, Quan-Sheng
Hao, Wei
Si, Tian-Mei
Wang, Chuan-Yue
Lee, Edwin H M
He, Yan-Ling
Yang, Shu-Yu
Chong, Mian-Yoon
Kua, Ee-Heok
Fujii, Senta
Sim, Kang
Yong, Michael K H
Trivedi, Jitendra K
Chung, Eun-Kee
Udomratn, Pichet
Chee, Kok-Yoon
Sartorius, Norman
Tan, Chay-Hoon
Shinfuku, Naotaka
Journal Article
Int J Geriatr Psychiatry. 2014 Apr
doi: 10.1002/gps.4011. Epub 2013 Aug 13.
URI: https://open-access.imh.com.sg/handle/123456789/4760
Authors Address: Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China
Beijing Anding Hospital, Capital Medical University, Beijing, China.
Appears in Collections:2014

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