Title: Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis
year: 2014
Journal: Schizophr Bull
Volume: 40
Issue: 4
Pages: 904-13
Epubdate: 19/07/2013
date: Jul
Alternate Journal: Schizophrenia bulletin
ISSN: 0586-7614
DOI: 10.1093/schbul/sbt093
PMCID: PMC4059431
Accession Number: 23861539
Abstract: Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal striatal abnormalities in the emergence of psychotic symptoms, contrasting with earlier findings implicating the ventral striatum. Our aims here were to characterize putative dorsal and ventral striatal circuit-level abnormalities in ARMS individuals using resting-state functional magnetic resonance imaging (fMRI) and to investigate their relationship to positive psychotic symptoms. Resting-state fMRI was acquired in 74 ARMS subjects and 35 matched healthy controls. An established method for mapping ventral and dorsal striatal functional connectivity was used to examine corticostriatal functional integrity. Positive psychotic symptoms were assessed using the Comprehensive Assessment of At-Risk Mental State and the Positive and Negative Syndrome Scale. Compared with healthy controls, ARMS subjects showed reductions in functional connectivity between the dorsal caudate and right dorsolateral prefrontal cortex, left rostral medial prefrontal cortex, and thalamus, and between the dorsal putamen and left thalamic and lenticular nuclei. ARMS subjects also showed increased functional connectivity between the ventral putamen and the insula, frontal operculum, and superior temporal gyrus bilaterally. No differences in ventral striatal (ie, nucleus accumbens) functional connectivity were found. Altered functional connectivity in corticostriatal circuits were significantly correlated with positive psychotic symptoms. Together, these results suggest that risk for psychosis is mediated by a complex interplay of alterations in both dorsal and ventral corticostriatal systems.
Notes: 1745-1701
Dandash, Orwa
Fornito, Alex
Lee, Jimmy
Keefe, Richard S E
Chee, Michael W L
Adcock, R Alison
Pantelis, Christos
Wood, Stephen J
Harrison, Ben J
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
Schizophr Bull. 2014 Jul
40(4):904-13. doi: 10.1093/schbul/sbt093. Epub 2013 Jul 16.
URI: https://open-access.imh.com.sg/handle/123456789/4764
Authors Address: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Department of General Psychiatry 1 and Research Division, Institute of Mental Health, Buangkok, Singapore
Office of Clinical Sciences, Graduate Medical School, Duke-National University of Singapore, Singapore, Singapore
Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
Neuroscience and Behavioral Disorders Program, Graduate Medical School, Duke-National University of Singapore, Singapore, Singapore
Department of Psychiatry and Behavioral Sciences and Center for Cognitive Neuroscience, Duke University, Durham, NC
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Melbourne Health, Melbourne, Australia
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK s.j.wood@bham.ac.uk.
Appears in Collections:2014




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