Title: Baseline social amotivation predicts 1-year functioning in UHR subjects: A validation and prospective investigation
year: 2015
Journal: Eur Neuropsychopharmacol
Volume: 25
Issue: 12
Pages: 2187-96
Epubdate: 11/11/2015
date: Dec
Alternate Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 0924-977x
DOI: 10.1016/j.euroneuro.2015.10.007
Accession Number: 26553972
Abstract: Social amotivation and diminished expression have been reported to underlie negative symptomatology in schizophrenia. In the current study we sought to establish and validate these negative symptom domains in a large cohort of schizophrenia subjects (n=887) and individuals who are deemed to be Ultra-High Risk (UHR) for psychosis. Confirmatory factor analysis conducted on PANSS item domains demonstrate that the dual negative symptom domains exist in schizophrenia and UHR subjects. We further sought to examine if these negative symptom domains were associated with functioning in UHR subjects. Linear regression analyses confirmed that social amotivation predicted functioning in UHR subjects prospectively at 1 year follow up. Results suggest that the association between social amotivation and functioning is generalisable beyond schizophrenia populations to those who are at-risk of developing psychosis. Social amotivation may be an important dimensional clinical construct to be studied across a range of psychiatric conditions.
Notes: 1873-7862
URL: http://www.europeanneuropsychopharmacology.com/article/S0924-977X(15)00332-6/abstract
URI: https://open-access.imh.com.sg/handle/123456789/4783
Authors Address: Research Division, Institute of Mental Health, Singapore, Singapore.
Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Canada
Institute of Medical Science, University of Toronto, Canada
Department of Psychiatry, University of Toronto, Canada.
Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Canada
Department of Psychiatry, University of Toronto, Canada.
Department of Psychiatry and Psychotherapy, University of Cologne, Germany.
Research Division, Institute of Mental Health, Singapore, Singapore
Department of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore
Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address: jimmy_lee@imh.com.sg.
Database Provider: Nlm
language: eng
Appears in Collections:2015

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