Title: An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids
year: 2015
Journal: Ann Acad Med Singapore
Volume: 44
Issue: 3
Pages: 85-91
Epubdate: 18/04/2015
date: Mar
Alternate Journal: Annals of the Academy of Medicine, Singapore
ISSN: 0304-4602 (Print)
Accession Number: 25882235
Abstract: INTRODUCTION: Incidental reports collected in clinical trials suggest that amongst participants, omega-3 fatty acids derived from fish oil ('omega-3') may be difficult to blind. MATERIALS AND METHODS: We conducted a systematic evaluation of blinding success in a 24-week trial of omega-3 versus an oil-based placebo. Within 1 week of supplement commencement (Week 1), a blinding questionnaire was completed by 131 children enrolled in a trial of omega-3 for the treatment of disruptive behaviour disorders. A version of the questionnaire was also completed by their parents at Week 1, and by the children at the end of supplement administration (Week 24). RESULTS: Participants were unable to differentiate omega-3 from placebo, and accuracy did not improve as a function of: the confidence of guesses, reason for guesses, notice of any change, beliefs about what should change, or time. Child and parent guesses also showed high concordance. CONCLUSION: Taken together, these data provide strong evidence that the identity of omega-3 can be blinded to participants.
Notes: Liu, Jean C J
Ann Acad Med Singapore. 2015 Mar
44(3):85-91.
URI: https://open-access.imh.com.sg/handle/123456789/4797
Authors Address: Division of Social Sciences, Yale-NUS College, Singapore.
Database Provider: Nlm
language: eng
Appears in Collections:2015

Files in This Item:
There are no files associated with this item.



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.