|Title:||An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids|
|Journal:||Ann Acad Med Singapore|
|Alternate Journal:||Annals of the Academy of Medicine, Singapore|
|Abstract:||INTRODUCTION: Incidental reports collected in clinical trials suggest that amongst participants, omega-3 fatty acids derived from fish oil ('omega-3') may be difficult to blind. MATERIALS AND METHODS: We conducted a systematic evaluation of blinding success in a 24-week trial of omega-3 versus an oil-based placebo. Within 1 week of supplement commencement (Week 1), a blinding questionnaire was completed by 131 children enrolled in a trial of omega-3 for the treatment of disruptive behaviour disorders. A version of the questionnaire was also completed by their parents at Week 1, and by the children at the end of supplement administration (Week 24). RESULTS: Participants were unable to differentiate omega-3 from placebo, and accuracy did not improve as a function of: the confidence of guesses, reason for guesses, notice of any change, beliefs about what should change, or time. Child and parent guesses also showed high concordance. CONCLUSION: Taken together, these data provide strong evidence that the identity of omega-3 can be blinded to participants.|
|Notes:||Liu, Jean C J|
Ann Acad Med Singapore. 2015 Mar
|Authors Address:||Division of Social Sciences, Yale-NUS College, Singapore.|
|Appears in Collections:||2015|
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