Title: What does schizophrenia teach us about antipsychotics?
year: 2015
Journal: Can J Psychiatry
Volume: 60
Issue: 3 Suppl 2
Pages: S14-8
Epubdate: 18/04/2015
date: Mar
Alternate Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie
ISSN: 0706-7437
PMCID: PMC4418619
Accession Number: 25886675
Abstract: OBJECTIVE: To examine how advances in our understanding of schizophrenia have shaped thinking about antipsychotics (APs) and their role in treatment. METHOD: Three specific developments in the field of schizophrenia are highlighted: advances in knowledge related to the earliest stages of schizophrenia, specifically the prodrome; reconceptualization of schizophrenia as an illness of multiple symptom domains; and greater clarification regarding the efficacy of clozapine and a new generation of APs. RESULTS: Evidence indicating that negative and cognitive symptoms are present during the prodrome suggests that intervention at the time of first-episode psychosis constitutes late intervention. The limited efficacy of APs beyond psychosis argues against a magic bullet approach to schizophrenia and for polypharmacy that is symptom domain-specific. Clozapine's unique, but limited, efficacy in treatment resistance supports subtyping schizophrenia based on treatment response. CONCLUSIONS: Advances in our understanding of schizophrenia have important implications regarding the current use of APs, expectations regarding response, and future drug development.
Notes: 1497-0015
Can J Psychiatry. 2015 Mar
60(3 Suppl 2):S14-8.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418619/pdf/cjp-2015-vol60-april-supplement-s14-s18.pdf
URI: https://open-access.imh.com.sg/handle/123456789/4811
Authors Address: Professor, Department of Psychiatry, University of Toronto, Toronto, Ontario
Lead, Subspecialty Clinics, Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario
Senior Scientist, Campbell Family Mental Health Research Institute, Toronto, Ontario
Faculty, Institute of Medical Science, Toronto, Ontario.
Database Provider: NLM
language: eng
Appears in Collections:2015

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