Title: Impact of duration of untreated psychosis and premorbid intelligence on cognitive functioning in patients with first-episode schizophrenia
year: 2016
Journal: Schizophr Res
Volume: 175
Issue: 01/03/2017
Pages: 97-102
Epubdate: 06/05/2016
date: Aug
Alternate Journal: Schizophrenia research
ISSN: 0920-9964
Article Number: 27146474
Keywords: Cognition Cognitive reserve Duration of untreated psychosis (DUP) Premorbid intelligence Psychosis Schizophrenia
Abstract: BACKGROUND: The neurotoxic hypothesis suggests that psychosis is toxic to the brain leading to clinical consequences. In this study, we hypothesized that a longer duration of untreated psychosis (DUP) in first episode schizophrenia (FES) patients is associated with poorer cognitive functioning, and that higher premorbid intelligence buffers against DUP-related cognitive impairment. METHOD: Eighty-one FES patients completed a neuropsychological battery, the Brief Assessment of Cognition in Schizophrenia (BACS). Composite scores of the BACS, which were normalized to a matched healthy control of seventy-three subjects, were used as an index of general cognition. A median split using the Wide Range Achievement Test-Reading Test scores was used to divide the patients into low versus high premorbid IQ groups. Hierarchical linear regression was performed to examine predictors of general cognition, including DUP. RESULTS: Longer DUP was found to be a significant predictor of poorer general cognition. In addition, DUP predicted general cognition in the low premorbid IQ group but not in the high premorbid IQ group. CONCLUSIONS: Our findings demonstrate that longer DUP in FES patients is associated with worse cognitive scores, and that this association is more pronounced in a subgroup of patients who have lower premorbid intelligence. Our results suggest the importance of earlier identification and management of patients with low premorbid IQ, given that their cognition may be more vulnerable to the toxicity of psychosis.
Notes: 1573-2509 Wang, M Y Ho, N F Sum, M Y Collinson, S L Sim, K Journal Article Netherlands Schizophr Res. 2016 Aug;175(1-3):97-102. doi: 10.1016/j.schres.2016.04.002. Epub 2016 Apr 14.
URL: http://www.sciencedirect.com/science/article/pii/S0920996416301347
URI: https://open-access.imh.com.sg/handle/123456789/4978
Authors Address: Research Division, Institute of Mental Health, Singapore. Department of Psychology, National University of Singapore, Singapore. Research Division, Institute of Mental Health, Singapore; General Psychiatry, Institute of Mental Health, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: kang_sim@imh.com.sg.
Database Provider: NLM
language: eng
Appears in Collections:2016

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