Title: Dopamine D1 signaling organizes network dynamics underlying working memory
year: 2016
Journal: Sci Adv
Volume: 2
Issue: 6
Pages: e1501672
Epubdate: 08/07/2016
date: Jun
Alternate Journal: Science advances
ISSN: 2375-2548
Legal note: PMC4928887
Article Number: 27386561
Keywords: Neuroscience dopamine working memory
Abstract: Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, mean cortical D1 density predicted working memory-emergent decoupling of the frontoparietal and default networks, which respectively manage task-related and internal stimuli. In contrast, striatal D1 predicted opposing effects within these two networks but no between-network effects. These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D1 signaling on the level of cortical microcircuits.
Notes: 2375-2548 Roffman, Joshua L Tanner, Alexandra S Eryilmaz, Hamdi Rodriguez-Thompson, Anais Orcid: 0000-0002-3926-8958 Silverstein, Noah J Ho, New Fei Nitenson, Adam Z Chonde, Daniel B Orcid: 0000-0001-7067-2628 Greve, Douglas N Abi-Dargham, Anissa Buckner, Randy L Manoach, Dara S Orcid: 0000-0001-9208-1167 Rosen, Bruce R Orcid: 0000-0002-8576-0839 Hooker, Jacob M Catana, Ciprian S10 RR022976/RR/NCRR NIH HHS/United States K23 MH084059/MH/NIMH NIH HHS/United States S10 RR017208/RR/NCRR NIH HHS/United States S10 RR026666/RR/NCRR NIH HHS/United States R01 MH101425/MH/NIMH NIH HHS/United States R21 EB018964/EB/NIBIB NIH HHS/United States S10 RR019933/RR/NCRR NIH HHS/United States P41 EB015896/EB/NIBIB NIH HHS/United States R01 NS083534/NS/NINDS NIH HHS/United States S10 RR023401/RR/NCRR NIH HHS/United States Journal Article United States Sci Adv. 2016 Jun 3;2(6):e1501672. doi: 10.1126/sciadv.1501672. eCollection 2016 Jun.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928887/pdf/1501672.pdf
URI: https://open-access.imh.com.sg/handle/123456789/4989
Authors Address: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. Department of Psychiatry, Columbia University Medical Center, Harkness Pavilion, 180 Fort Washington Avenue, New York, NY 10032, USA.
Database Provider: NLM
language: eng
Appears in Collections:2016

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