Title: Association between serum levels of bioavailable vitamin D and negative symptoms in first-episode psychosis
year: 2016
Journal: Psychiatry Res
Volume: 243
Pages: 390-4
Epubdate: 28/07/2016
date: 01/09/1930
Alternate Journal: Psychiatry research
ISSN: 0165-1781
Article Number: 27449008
Keywords: First-episode psychosis Schizophrenia Tropical Vitamin D
Abstract: Total vitamin D levels had been commonly reported to be lowered in patients with chronic psychotic illnesses in countries from the higher latitudes. However, studies on patients with first episode psychosis (FEP) are limited. In this study we investigated serum concentrations of total and bioavailable vitamin D levels in FEP patients compared to healthy controls and the association between symptom severity and vitamin D components. A total of 31 FEP patients and 31 healthy controls were recruited from Institute of Mental Health, Singapore. FEP patients were identified using Structured Clinical Interview for DSM-IV Axis I disorders (SCID-1) and severity symptoms were assessed using the positive and negative syndrome scale (PANSS). Sera from participants were analyzed for total vitamin D, vitamin D-binding protein (DBP) and bioavailable vitamin D. Linear regressions were performed to examine the associations between serum total and bioavailable vitamin D and the PANSS subscales. Current study noted a significantly lower bioavailable vitamin D was in the FEP group and an association between bioavailable vitamin D and negative symptoms in FEP patients in a population with a consistent supply of sun exposure throughout the year.
Notes: 1872-7123 Yee, Jie Yin See, Yuen Mei Abdul Rashid, Nur Amirah Neelamekam, Sasi Lee, Jimmy Journal Article Ireland Psychiatry Res. 2016 Sep 30;243:390-4. doi: 10.1016/j.psychres.2016.07.003. Epub 2016 Jul 5.
URL: http://ac.els-cdn.com/S0165178116302700/1-s2.0-S0165178116302700-main.pdf?_tid=bd89d34c-ffe2-11e6-87d6-00000aab0f6c&acdnat=1488526178_c1a650e0c0b523544c4e0a4742c55777
URI: https://open-access.imh.com.sg/handle/123456789/4997
Authors Address: Research Division, Institute of Mental Health, Singapore. Electronic address: jie_yin_yee@imh.com.sg. Research Division, Institute of Mental Health, Singapore. Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2016

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