Title: Psychosis, Treatment Emergent Extrapyramidal Events, and Subsequent Onset of Huntington's Disease: A Case Report and Review of the Literature
year: 2016
Journal: Clin Psychopharmacol Neurosci
Volume: 14
Issue: 3
Pages: 302-4
Epubdate: 05/08/2016
date: 01/08/1931
Alternate Journal: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
ISSN: 1738-1088 (Print) 1738-1088
Legal note: PMC4977814
Article Number: 27489386
Keywords: Extrapyramidal side effects Huntington's disease Neuropsychiatric manifestations Schizophrenia
Abstract: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by a triad of progressive motor dysfunction, cognitive decline and psychiatric disturbances. The hallmark of HD is the distinctive choreiform movement disorder that typically has a subtle, insidious onset in the fourth to fifth decade of life and gradually worsens over 10 to 20 years until death. Notably, two-thirds of HD patients present with chorea and one third with mental changes. The prevalence of psychiatric symptoms is significantly higher than in the general population, and is estimated to be around 66-73%. Here, we report a unique case of subsequent onset of HD in a patient previously treated for schizophrenia and complicated by the extrapyramidal side effects to antipsychotics.
Notes: Xu, Changqing Yogaratnam, Jegan Tan, Nigel Sim, Kang Case Reports Korea (South) Clin Psychopharmacol Neurosci. 2016 Aug 31;14(3):302-4. doi: 10.9758/cpn.2016.14.3.302.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977814/pdf/cpn-14-302.pdf
URI: https://open-access.imh.com.sg/handle/123456789/5015
Authors Address: Institute of Mental Health/Woodbridge Hospital, Singapore. National Neuroscience Institute, Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2016

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