Title: Disrupted Working Memory Circuitry in Schizophrenia: Disentangling fMRI Markers of Core Pathology vs Other Aspects of Impaired Performance
year: 2016
Journal: Neuropsychopharmacology
Volume: 41
Issue: 9
Pages: 2411-20
Epubdate: 23/04/2016
date: Aug
Alternate Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 0893-133x
Legal note: PMC4946071
Article Number: 27103065
Abstract: Working memory (WM) impairment, a core feature of schizophrenia, is often associated with aberrant dorsolateral prefrontal cortex (dlPFC) activation. Reduced resting-state connectivity within the frontoparietal control network (FPCN) has also been reported in schizophrenia. However, interpretation of WM-related dlPFC dysfunction has been limited by performance differences between patients and controls, and by uncertainty over the relevance of resting-state connectivity to network engagement during task. We contrasted brain activation in 40 schizophrenia patients and 40 controls during verbal WM performance, and evaluated underlying functional connectivity during rest and task. During correct trials, patients demonstrated normal FPCN activation, despite an inverse relationship between positive symptoms and activation. FPCN activation differed between the groups only during error trials (controls>patients). In contrast, controls demonstrated stronger deactivation of the ventromedial prefrontal cortex (vmPFC) during correct and error trials. Functional connectivity analysis indicated impaired resting-state FPCN connectivity in patients, but normal connectivity during task. However, patients showed abnormal connectivity among regions such as vmPFC, lateral orbitofrontal cortex, and parahippocampal gyrus (PHG) during both rest and task. During task, patients also exhibited altered thalamic connectivity to PHG and FPCN. Activation and connectivity patterns that were more characteristic of controls generally correlated with better performance. In summary, patients demonstrated normal FPCN activation when they remained on-task, and exhibited normal FPCN connectivity during WM, whereas vmPFC deactivation differences persisted regardless of WM performance. Our findings suggest that altered FPCN activation in patients reflects performance difference, and that limbic and thalamic dysfunction is critically involved in WM deficits in schizophrenia.
Notes: 1740-634x Eryilmaz, Hamdi ORCID: http://orcid.org/0000-0002-8599-4504 Tanner, Alexandra S Ho, New Fei Nitenson, Adam Z Silverstein, Noah J Petruzzi, Liana J Goff, Donald C Manoach, Dara S Roffman, Joshua L K23 MH084059/MH/NIMH NIH HHS/United States R01 MH101425/MH/NIMH NIH HHS/United States S10 RR023043/RR/NCRR NIH HHS/United States S10 RR023401/RR/NCRR NIH HHS/United States Journal Article England Neuropsychopharmacology. 2016 Aug;41(9):2411-20. doi: 10.1038/npp.2016.55. Epub 2016 Apr 22.
URI: https://open-access.imh.com.sg/handle/123456789/5042
Authors Address: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Department of Psychiatry, New York University Langone Medical Center and Nathan Kline Institute, New York, NY, USA.
Database Provider: NLM
language: eng
Appears in Collections:2016

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