Title: The effect of adjuvant remifentanil with propofol or thiopentone on seizure quality during electroconvulsive therapy
year: 2016
Journal: Anaesth Intensive Care
Volume: 44
Issue: 2
Pages: 278-80
Epubdate: 01/04/2016
date: Mar
Alternate Journal: Anaesthesia and intensive care
ISSN: 0310-057X (Print) 0310-057x
Article Number: 27029661
Keywords: Adult Aged Case-Control Studies *Electroconvulsive Therapy Electroencephalography/drug effects Female Humans Male Middle Aged Piperidines/*administration & dosage Propofol/*administration & dosage Retrospective Studies Seizures/*therapy Thiopental/*administration & dosage Electroconvulsive therapy remifentanil
Abstract: In order to optimise outcome to Electro Convulsive therapy (ECT), there has been a trend to utilise remifentanil as an adjunct to standard intravenous induction agents. This has allowed a reduction in the dose of anaesthetic agent, and usually an improved response to stimulation. However there have been no previous studies to ascertain whether this improvement is simply as a result of the reduced dose of anaesthetic agent or whether remifentanil itself might possess epileptogenic properties. This retrospective case-controlled study examined ECT outcomes, determined by EEG quality analysis, in patients who received ECT with or without remifentanil, where there was no dose reduction in the anaesthetic agent. There were no improvements seen in the measurements of any EEG parameter, including seizure duration. These observations suggest that remifentanil does not possess any intrinsic pro-convulsant activity and that any improvement in outcome seen with its use is as a result of dose reduction in the IV anaesthetic agent.
Notes: MacPherson, R Marroquin-Harris, M Galvez, V Tor, P Loo, C Journal Article Australia Anaesth Intensive Care. 2016 Mar;44(2):278-80.
URI: https://open-access.imh.com.sg/handle/123456789/5058
Authors Address: Royal North Shore Hospital, Sydney. Royal North Shore Hospital. Department of Psychiatry, University of New South Wales.
Database Provider: NLM
language: eng
Appears in Collections:2016

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