Title: A systematic review on comorbid post-traumatic stress disorder in schizophrenia
year: 2016
Journal: Schizophr Res
Volume: 176
Issue: 02/03/2017
Pages: 441-51
Epubdate: 28/05/2016
date: Oct
Alternate Journal: Schizophrenia research
ISSN: 0920-9964
Article Number: 27230289
Keywords: Comorbidity Post-traumatic stress disorder Schizophrenia
Abstract: Post-traumatic stress disorder (PTSD) appears to commonly co-occur with schizophrenia, which is widely considered the most disabling mental illness. Both conditions share neurological risk factors, and present with symptoms that are superficially similar, complicating diagnostic accuracy. The presence of comorbid PTSD is also of concern as additional diagnoses tend to worsen functioning and quality of life. In the current review, EMBASE, Medline, and PsycINFO were searched for articles pertaining to PTSD comorbidity in schizophrenia spectrum disorders. Articles went through two stages of review prior to inclusion - one at the abstract level and another at the full-text level. Thirty-four articles were ultimately included in the present review. Prevalence of PTSD in schizophrenia ranged from 0 to 57%, likely due to study heterogeneity. Findings generally indicated that comorbid PTSD was associated with higher levels of positive symptoms, general psychopathology, and neurocognitive impairment, as well as worse functioning and quality of life. As such, it is important for clinicians to differentiate between psychotic and PTSD symptoms, and to pay attention to the associated features of comorbid PTSD in order to provide the most appropriate intervention. Unfortunately, epidemiological and longitudinal studies in this area are lacking.
Notes: 1573-2509 Seow, Lee Seng Esmond Ong, Clarissa Mahesh, Mithila Valli Sagayadevan, Vathsala Shafie, Saleha Chong, Siow Ann Subramaniam, Mythily Journal Article Review Netherlands Schizophr Res. 2016 Oct;176(2-3):441-51. doi: 10.1016/j.schres.2016.05.004. Epub 2016 May 24.
URL: http://www.sciencedirect.com/science/article/pii/S0920996416302250
URI: https://open-access.imh.com.sg/handle/123456789/5072
Authors Address: Research Division, Institute of Mental Health, Singapore. Electronic address: esmond_LS_SEOW@imh.com.sg. Research Division, Institute of Mental Health, Singapore.
Database Provider: NLM
language: eng
Appears in Collections:2016

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