Title: Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
year: 2017
Journal: Nat Commun
Volume: 8
Pages: 14774
date: 01/03/2021
ISSN: 2041-1723 (Electronic);2041-1723 (Linking)
Legal note: PMC5364411
Article Number: 28322246
Abstract: We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
Notes: McLaughlin, Russell L;Schijven, Dick;van Rheenen, Wouter;van Eijk, Kristel R;O'Brien, Margaret;Kahn, Rene S;Ophoff, Roel A;Goris, An;Bradley, Daniel G;Al-Chalabi, Ammar;van den Berg, Leonard H;Luykx, Jurjen J;Hardiman, Orla;Veldink, Jan H;eng;U24 AG021886/AG/NIA NIH HHS/;U01 AG032984/AG/NIA NIH HHS/;U01 AG016976/AG/NIA NIH HHS/;R01 NS073873/NS/NINDS NIH HHS/;R01 HL105756/HL/NHLBI NIH HHS/;R01 AG033193/AG/NIA NIH HHS/;U01 MH109514/MH/NIMH NIH HHS/;R00 MH101367/MH/NIMH NIH HHS/;England;2017/03/23 06:00;Nat Commun. 2017 Mar 21;8:14774. doi: 10.1038/ncomms14774.
URL: https://www.ncbi.nlm.nih.gov/pubmed/28322246;https://air.unimi.it/retrieve/handle/2434/487990/813983/McLaughlin%20R.L.%20Nature%20Communication%202017.pdf
URI: https://open-access.imh.com.sg/handle/123456789/5150
Authors Address: Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin DO2 DK07, Republic of Ireland.;Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 DK07, Republic of Ireland.;Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.;Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.;Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.;Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA.;Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, Leuven B-3000, Belgium.;Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London WC2R 2LS, UK.;Department of Psychiatry, Hospital Network Antwerp (ZNA) Stuivenberg and Sint Erasmus, Antwerp 2020, Belgium.
Appears in Collections:2017

Files in This Item:
File Description SizeFormat 
McLaughlin-2017-Genetic correlation between am.pdf746.2 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.